Search results for "skin ulcers"
showing 4 items of 4 documents
Prolidase deficiency in two dermatological patients in western Sicily
2020
Prolidase deficiency is a rare disorder inherited through an autosomal recessive gene. The hallmark of the disorder are iminodipeptiduria, chronic skin ulcers, recurring infections, mental retardation and characteristic facial appearance, although prolidase deficiency can occur with no clinical manifestation. The primary biological function of the enzyme involves the metabolism of collagen degradation products and the recycling of proline for collagen resynthesis. We describe two patients with prolidase deficiency and review the different clinical manifestations suggesting the pathogenetic mechanism through few hypotheses.
Light-Tissue Interaction Model for the Analysis of Skin Ulcer Multi-spectral Images
2017
International audience; Skin ulcers (SU) are ones of the most frequent causes of consultation in primary health-care units (PHU) in tropical areas. However, the lack of specialized physicians in those areas, leads to improper diagnosis and management of the patients. There is then a need to develop tools that allow guiding the physicians toward a more accurate diagnosis. Multi-spectral imaging systems are a potential non-invasive tool that could be used in the analysis of skin ulcers. With these systems it is possible to acquire optical images at different wavelengths which can then be processed by means of mathematical models based on optimization approaches. The processing of those kind o…
Polarization-sensitive hyperspectral imaging of human skin: From system design to clinical validation (Conference Presentation)
2020
We present the development and validation of a new approach for quantitative functional imaging of human skin based on the machine learning technique for the analysis of the hyperspectral skin images. The considered skin parameters include blood volume fraction, blood oxygenation, melanin content, and the epidermal layer thickness. Additionally, the degree of residual polarization of the reflected light has been analyzed. The validity of the approach has been confirmed by the initial preclinical tests with the tissue-mimicking phantoms, functional in-vivo skin tests, and pilot clinical study of type II diabetic patients. The proposed technique has great potential to be implemented in clinic…
Clinical conditions responsible for hyperviscosity and skin ulcers complications
2017
In this brief review, we have examined some clinical conditions that result to be associated to an altered hemorheological profile and at times accompanied by skin ulcers. This skin condition may be observed in patients with the following condtions, such as primary polycythemic hyperviscosity (polycythemia, thrombocytemia) treated with hydroxyurea, primary plasma hyperviscosity (multiple myeloma, cryoglobulinemia, cryofibrinogenemia, dysfibrinogenemia, and connective tissue diseases), primary sclerocythemic hyperviscosity (hereditary spherocytosis, thalassemia, and sickle cell disease). In addition, it may be present in patients with secondary hyperviscosity conditions such as diabetes mell…